Pharmacokinetics

Absorption: Rapidly and completely absorbed following oral administration

Distribution: Unknown

Protein Binding: 20–25% bound to plasma proteins

Metabolism and Excretion: 34–50% excreted unchanged by the kidneys

Half-life: 11–16 hr initially; drops to 2–9 hr after 2 wk of therapy

TIME/ACTION PROFILE (adrenal suppression)

ROUTE	ONSET	PEAK†	DURATION
PO	3–5 days	1.5 hr	72 hr‡

†Blood levels
‡Recovery of adrenal function after discontinuation of short-term therapy; may take longer (up to 1 yr) after chronic therapy

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