Pharmacokinetics
Absorption: IV administration results in complete bioavailability. Slowly and variably absorbed from the GI tract (35–65%)
Distribution: Distributed to and accumulates slowly in body tissues. Reaches high levels in fat, muscle, liver, lungs, and spleen. Crosses the placenta and enters breast milk
Protein Binding: 96% bound to plasma proteins
Metabolism and Excretion: Metabolized by the liver, excreted into bile. Minimal renal excretion. One metabolite has antiarrhythmic activity
Half-life: 13–107 days
TIME/ACTION PROFILE (suppression of ventricular arrhythmias)
| ROUTE | ONSET | PEAK | DURATION |
| PO | 2–3 days (up to 2–3 mos) | 3–7 hr | wks–mos |
| IV | 2 hr | 3–7 hr | unknown |
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