Implementation

• Do not confuse Elavil (amitriptyline) with Oruvail (ketoprofen)

» Dose increases should be made at bedtime because of sedation. Dose titration is a slow process; may take weeks to months. May give entire dose at bedtime. Sedative effect may be apparent before antidepressant effect is noted. May require tapering to avoid withdrawal effects

• PO: Administer medication with or immediately after a meal to minimize gastric upset. Tablet may be crushed and given with food or fluids

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