Pharmacokinetics
Absorption: Well absorbed from the GI tract
Distribution: Widely distributed
Protein Binding: 95% bound to plasma proteins
Metabolism and Excretion: Extensively metabolized by the liver. Some metabolites have antidepressant activity. Undergoes enterohepatic recirculation and secretion into gastric juices. Probably crosses the placenta and enters breast milk
Half-life: 10–50 hr
TIME/ACTION PROFILE (antidepressant effect)
| ROUTE | ONSET | PEAK | DURATION |
| PO | 2–3 wk (up to 30 days) | 2–6 wk | days–wks |
| IM | 2–3 wk | 2–6 wk | days–wks |
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