Contraindication/Precautions

Contraindicated in:

• Angle-closure glaucoma

• Known history of QTc prolongation, recent MI, heart failure

• May risk of suicide attempt/ideation especially during dose early treatment or dose adjustment; risk may be greater in children or adolescents

• Patients with pre-existing cardiovascular disease

• Prostatic hyperplasia (increased risk of urinary retention)

• History of seizures (threshold may be )

• OB: Use only if clearly needed and maternal benefits outweigh risk to fetusLactation: May cause sedation in infant

• Pedi: Safety not established in children <12 yr

• Geri: Appears on Beers list. Geriatric patients are at increased risk of adverse reactions including falls secondary to sedative and anticholinergic effects

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