Assessment

• Assess patient for signs of metabolic alkalosis (hypoventilation) during therapy

• Monitor patient for signs of hepatic function impairment (ammonia retention with intoxication, hepatic coma), especially in patients with uremia, cirrhosis, or hepatitis

• Monitor serum bicarbonate levels to determine dose

» Monitor arterial blood gases

• Monitor patient for symptoms of ammonia toxicity (pallor, sweating, retching, bradycardia, arrhythmias, hyperventilation, local and general twitching, tonic convulsions, coma)

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