Interactions

Drug-Drug

• Additive CNS depression with other CNS depressants including alcohol, antidepressants, antihistamines, opioid analgesics, and other sedative/hypnotics

• Sedation may be prolonged with MAO inhibitors and valproic acid

• Induces hepatic enzymes that metabolize other drugs, decreasing their effectiveness, including hormonal contraceptives, furosemide, disopyramide, propafenone, methadone, cimetidine, cyclosporine, tacrolimus, rifampin, estrogen, chloramphenicol, acebutolol, propranolol, metoprolol, timolol, doxycycline, corticosteroids, tricyclic antidepressants, warfarin, theophylline, and quinidine

• Concomitant use of kava, valerian, skullcap, chamomile, or hops can increase CNS depression

• St. John's wort may decrease barbiturate effect

amobarbital is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.