Route/Dosage

Most Infections

• PO (Adults): 250–500 mg q 8 hr
or 500–875 mg q 12 hr (not to exceed 2–3 g/day).

• PO (Adults and Children >=12 yr):
Extended-release tablets (for Strep throat)-775 mg once daily for 10 days.

• PO (Children >3 mo): 25–50 mg/kg/day in divided doses q 8 hr
or 25–50 mg/kg/day individual doses q 12 hr;
Acute otitis media due to highly resistant strains of S. pneumoniae—80–90 mg/kg/day divided q 12 hr;
Postexposure inhalational anthrax prophylaxis—<40 kg: 45 mg/kg/day in divided doses q 8 hr; >40 kg: 500 mg q 8 hr.

• PO (Infants <=3 mo and neonates): 20–30 mg/kg/day in divided doses q 12 hr.

• PO (Adults):
Triple therapy—1000 mg amoxicillin twice daily with lansoprazole 30 mg twice daily and clarithromycin 500 mg twice daily for 14 days
or1000 mg amoxicillin twice daily with omeprazole 20 mg twice daily and clarithromycin 500 mg twice daily for 14 days
or amoxicillin 1000 mg twice daily with esomeprazole 40 mg daily and clarithromycin 500 mg twice daily for 10 days.
Dual therapy—1000 mg amoxicillin three times daily with lansoprazole 30 mg three times daily for 14 days.

• PO (Adults): 2 g 1 hr prior to procedure.

• PO (Children): 50 mg/kg 1 hr prior to procedure (not to exceed adult dose).

• PO (Adults and Children >=40 kg): single 3 g dose.

• PO (Children >2 yr and <40 kg): 50 mg/kg with probenecid 25 mg/kg as a single dose.

• PO (Adults CCr 10–30 ml/min): 250–500 mg q 12 hr.

• PO (Adults CCr <10 ml/min): 250–500 mg q 24 hr.

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