amoxicillin/clavulanate

Route/Dosage

Most Infections (Dosing based on amoxicillin component)

• PO (Adults and Children >40 kg): 250 mg q 8 hr or 500 mg q 12 hr..

• PO (Adults and Children >40 kg): 875 mg q 12 hr or 500 mg q 8 hr; Acute bacterial sinusitis—2000 mg q 12 hr for 10 days as extended release (XR) product; Community-acquired pneumonia—2000 mg every 12 hr for 7–10 days as extended release (XR) product..

• PO (Children <40 kg): 80–90 mg/kg/day in divided doses q 12 hr for 10 days (as ES formulation only)..

• PO (Adults): CCr 10–30 mL/min—250–500 mg q 12 hr (do not use 875 mg tablet); CCr <10 mL/min—250–500 mg q 24 hr..

• PO (Children ≥3 mo): 200 mg/5 mL or 400 mg/5 mL suspension—45 mg/kg/day divided q 12 hr; 125 mg/5 mL or 250 mg/5 mL suspension—40 mg/kg/day divided q 8 hr..

• PO (Children ≥3 mo): 200 mg/5 mL or 400 mg/5 mL suspension—25 mg/kg/day divided q 12 hr or 20 mg/kg/day divided q 8 hr (as 125 mg/5 mL or 250 mg/5 mL suspension)..

• PO (Children <3 mo): 15 mg/kg q 12 hr (125 mg/mL suspension recommended)..