Pharmacokinetics

Absorption: Well absorbed after oral administration

Distribution: Widely distributed in body tissues, with high concentrations in the brain and CSF. Crosses placenta and enters breast milk

Metabolism and Excretion: Some metabolism by the liver. Urinary excretion is pH-dependent. Alkaline urine promotes reabsorption and prolongs action

Half-life: Children 6–12 yrs: 9–11 hr; Adults: 10–13 hr (depends on urine pH)

TIME/ACTION PROFILE (CNS stimulation)

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