Interactions

Drug-Drug

• Use with MAO inhibitors or meperidine can result in hypertensive crisis

• ↑ adrenergic effects with other adrenergics or thyroid preparations

• Drugs that alkalinize urine ( sodium bicarbonate , acetazolamide ) ↓ excretion, ↑ effects

• Drugs that acidify urine ( ammonium chloride , large doses of ascorbic acid ) ↑ excretion, ↓ effects

• ↑ risk of hypertension and bradycardia with beta blockers

• ↑ risk of arrhythmias with digoxin

• Tricyclic antidepressants may ↑ effect of amphetamine but may ↑ risk of arrhythmias, hypertension, or hyperpyrexia

Drug-Natural Products
Use with St. John's wort may ↑ serious side effects (avoid concurrent use)

Drug-Food
Foods that alkalinize the urine (fruit juices) can ↑ effect of amphetamine

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