Action

• Binds to fungal cell membrane, allowing leakage of cellular contents

• Toxicity (especially acute infusion reactions and nephrotoxicity) is less with lipid formulations

Therapeutic Effect(s):
Can be fungistatic or fungicidal (depends on concentration achieved and susceptibility of organism)

Spectrum:
Active against

» Aspergillosis

» Blastomycosis

» Candidiasis

» Coccidioidomycosis

» Cryptococcosis

» Histoplasmosis

» Leishmaniasis (liposomal formulation only)

» Mucormycosis

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