Pharmacokinetics

Absorption: Not absorbed orally.

Distribution: Extensively distributed to body tissues and fluids. Poor penetration into CSF.

Metabolism and Excretion: Elimination is very prolonged. Detectable in urine up to 7 wk after discontinuation

Half-life: Biphasic—initial phase, 24–48 hr; terminal phase, 15 days. Cholesteryl sulfate—28 hr. Lipid complex—174 hr. Liposomal—100–153 hr

TIME/ACTION PROFILE (blood levels)

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