Interactions

Drug-Drug

• Increased risk of renal toxicity, bronchospasm, and hypotension with antineoplastics

• Concurrent use with corticosteroids risk of hypokalemia

• Concurrent use with zidovudine may increase the risk of myelotoxicity and nephrotoxicity

• Combined use with flucytosine antifungal activity but may the risk of toxicity from flucytosine

• Combined use with azole antifungals may induce fungal resistance

• Increased risk of nephrotoxicity with other nephrotoxic agents such as aminoglycosides, cyclosporine, or tacrolimus

• Hypokalemia from amphotericin the risk of digoxin toxicity

• Hypokalemia may enhance the curariform effects of neuromuscular blocking agents

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