Route/Dosage

• Specific dosage and duration of therapy depend on nature of infection being treated

• IV (Adults): Give test dose of 1 mg. If test dose tolerated, initiate therapy with 0.25 mg/kg/day (doses up to 1.5 mg/kg/day may be used, depending on type of infection) (alternate-day dosing may also be used);
Bladder irrigation—Instill 50 mcg/ml solution into bladder daily for 5–10 days.

• IV (Infants and Children): Give test dose of 0.1 mg/kg (maximum dose 1 mg) or may administer initial dose of 0.25–1 mg/kg/day over 6 hr (without test dose) (some infections may require 1.5 mg/kg/day; alternate-day dosing may be used).

• IT (Adults): 25–300 mcg q 48–72 hr, to 500 mcg—1 mg as tolerated (maximum total dose = 15 mg).

• IT (Children): 25–100 mcg q 48–72 hr; to 500 mcg as tolerated.

• IV (Adults and Children): 3–4 mg/kg q 24 hr (no test dose needed).

• IV (Adults and Children): 5 mg/kg q 24 hr (no test dose needed).

• IV (Adults and Children):
Empiric therapy—3 mg/kg q 24 hr;
Documented infections—3–5 mg/kg q 24 hr;
Visceral leishmaniasis (immunocompetent patients)—3 mg/kg q 24 hr on days 1–5, then 3 mg/kg q 24 hr on days 14 and 21;
Visceral leishmaniasis (immunosuppressed patients)—4 mg/kg q 24 hr on days 1–5, then 4 mg/kg q 24 hr on days 10, 17, 24, 31, and 38;
Cryptococcal meningitis in HIV patients—6 mg/kg q 24 hr.

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