Implementation

IM: Reconstitute for IM use by adding 3.2 ml of sterile water or 0.5% or 2% lidocaine HCl to the 1.5-g vial or 6.4 ml to the 3-g vial. Administer within 1 hr of preparation, deep IM into well-developed muscle

IV Adminstration:

• Direct IV:
Diluent: Reconstitute 1.5-g vial with 3.2 ml of sterile water for injection and the 3-g vial with 6.4 ml.
Concentration: 375 mg ampicillin/sulbactam per ml

• Rate:
Administer over at least 10–15 min within 1 hr of reconstitution. More rapid administration may cause seizures

• Intermittent Infusion:
Diluent: Reconstitute vials as per the directions above. Further dilute in 50–100 ml of 0.9% NaCl, D5W, D5/0.45% NaCl, or LR. Stability of solution varies from 2–8 hr at room temperature or 3–72 hr if refrigerated, depending on concentration and diluent.
Concentration: Final concentration of infusion should be 3–45 mg of ampicillin/sulbactam per ml

• Rate:
Infuse over 15–30 min

• Y-Site Compatibility:

» anidulafungin

» bivalirudin

» daptomycin

» fenoldopam

» filgrastim

» fluconazole

» granisetron

» hydromorphone

» levofloxacin

» linezolid

» palonosetron

» pantoprazole

» tacrolimus

» tirofiban

» voriconazole

• Y-Site Incompatibility:

» acyclovir

» amiodarone

» amphotericin B cholesteryl sulfate

» caspofungin

» cefotaxime

» cefoxitin

» ciprofloxacin

» diazepam

» dobutamine

» doxycycline

» ganciclovir

» haloperidol

» hydralazine

» hydroxyzine

» lansoprazole

» lorazepam

» methylprednisolone sodium succinate

» midazolam

» nicardipine

» ondansetron

» phenytoin

» prochlorperazine

» promethazine

» protamine

» quinupristin/dalfopristin

» trimethoprim/sulfamethoxazole

» verapamil

» If aminoglycosides and penicillins must be given concurrently, administer in separate sites at least 1 hr apart

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