Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Concurrent use of bepredil, dihydroergotamine, ergotamine, midazolam, and triazolam (may cause serious, potentially fatal toxicity)

• Concurrent use of rifampin or supplemental vitamin E

• If amprenavir is used concurrently with ritonavir, flecainide and propafenone are contraindicated

• Lactation: Potential for serious adverse reactions in nursing infants (and potential HIV transmission)

Use Cautiously in:

• Hypersensitivity to sulfonamides

• Hepatic impairment (dosage reduction required)

• Hemophilia (may increase bleeding)

• Diabetes mellitus (may worsen hyperglycemia)

• OB: Safety not established.

Exercise Extreme Caution in:
Concurrent use of amiodarone, parenteral lidocaine, tricyclic antidepressants, or quinidine (may produce potentially life-threatening drug interactions)

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