Interactions

Drug-Drug

• Increases blood levels and the risk of toxicity from midazolam, triazolam, ergot derivatives and pimozide; concurrent use is contraindicated; may also increase blood levels and effects of other benzodiazepines

• Increases blood levels and the risk of toxicity from amiodarone, lidocaine (parenteral), quinidine, tricyclic antidepressants, and warfarin; careful monitoring is required

• If ritonavir is used concurrently, additional use of flecainide or propafenone is contraindicated (increased risk of arrhythmias)

• Significantly increases blood levels of rifabutin; decrease dose by 50% if used concurrently

• May increase blood levels and toxicity of HMG CoA reductase inhibitors, erythromycin, dapsone, itraconazole, ketoconazole alprazolam, diazepam, flurazepam, calcium channel blockers, clozapine, carbamazepime, cyclosporine and tacrolimus and loratadine

• Concurrent use with sildenafil increases the risk of priapism, hypotension, and visual changes

• Rifampin significantly decreases blood levels and efficacy of amprenavir; concurrent use is contraindicated

• Phenobarbital, phenytoin, carbamazepine, dexamethasone efavirenz, delavirdine nevirapine and hormonal contraceptives decrease amprenavir levels and may decrease antiretroviral activity

• Cimetidine, indinavir, lopinavir, ritonavir, and nelfinavir may increase amprenavir levels (when used conconcurrently with ritonavir, amprenavir dosage should be decreased)

• Saquinavir may decrease levels

• Antacids and didanosine (due to buffer content) may decrease absorption (separate administration by 1 hr)

• Methadone decreasese amprenavir levels and amprenavir decreases methadone levels; dose adjustments may be necessary

Drug-Natural Products
Use with St. John's wort may cause decreased drug levels and effectiveness

Drug-Food
Ingestion of a high-fat meal may decrease absorption

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