anakinra

Contraindication/Precautions

Contraindicated in:

• Active infections;

• Hypersensitivity;

• Hypersensitivity to other Escherichia coli –derived products.

Use Cautiously in:

• Other chronic debilitating illness;

• Underlying immunosuppression;

• Renal impairment;

• OB: Lactation: Pedi: Safety not established;

• Geri: May be more sensitive to toxicity due to age-related decline in renal function; increased incidence of infection in geriatric population.

Exercise Extreme Caution in:
Concurrent use of TNF blocking agents such as etanercept (higher risk of serious infections).