Implementation

• Do not confuse bupropion with buspirone. Do not administer bupropion (Wellbutrin) with Zyban, which contain the same ingredients

» Administer doses in equally spaced time increments during the day to minimize the risk of seizures. Risk of seizures increases four fold in doses greater than 450 mg per day

» May be initially administered concurrently with sedatives to minimize agitation. This is not usually required after the 1st wk of therapy

» Insomnia may be decreased by avoiding bedtime doses. May require treatment during 1st wk of therapy

» May be administered with food to lessen GI irritation

» Nicotine patches, gum, inhalers, and spray may be used concurrently with bupropion

» When converting from other brands of bupropion to Aplenzin, 348 mg/day Aplenzin is equivalent to 300 mg/day bupropion HCl and 174 mg/day Aplenzin is equivalent to 150 mg/day bupropion HCl

• PO: Sustained-release or extended-release tablets should be swallowed whole; do not break, crush, or chew

• Seasonal Affective Disorder: Begin administration in autumn prior to the onset of depressive symptoms. Continue therapy through winter and begin to taper and discontinue in early spring

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