Davis's Drug Guide

busPIRone

Pharmacokinetics

Absorption: Rapidly absorbed

Distribution: Unknown

Protein Binding: 95% bound to plasma proteins

Metabolism and Excretion: Extensively metabolized by the liver (CYP3A4 enzyme system); 20–40% excreted in feces

Half-life: 2–3 hr

TIME/ACTION PROFILE (relief of anxiety)

ROUTEONSETPEAKDURATION
PO7–10 days3–4 wkunknown



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