Interactions

Drug-Drug

• Use with MAO inhibitors may result in hypertension and is not recommended

• Erythromycin, nefazodone, ketoconazole, itraconazole, ritonavir , and other inhibitors of CYP3A4 blood levels and effects of buspirone; dose reduction is recommended (decrease to 2.5 mg twice daily with erythromycin, decrease to 2.5 mg once daily with nefazodone)

• Rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, and other inducers of CYP3A4 blood levels and effects of buspirone; dose adjustment may be necessary

• Avoid concurrent use with alcohol

Drug-Natural Products
Concomitant use of kava, valerian, or chamomile can CNS depression

Drug-Food
Grapefruit juice serum levels and effect; ingestion of large amounts of grapefruit juice is not recommended

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