Interactions

Drug-Drug

• May metabolism of and therefore levels/ effectiveness of corticosteroids, doxycycline, felbamate, quinidine, warfarin, estrogen-containing contraceptives, barbiturates, cyclosporine, benzodiazepines, theophylline, lamotrigine, phenytoin, topiramate, valproic acid, bupropion, and haloperidol

• Danazol blood levels (avoid concurrent use if possible)

• Concurrent use (within 2 wk) of MAO inhibitors may result in hyperpyrexia, hypertension, seizures, and death

• Verapamil, diltiazem, propoxyphene, itraconazole, ketoconazole, erythromycin, clarithromycin, SSRIs, antidepressants, or cimetidine may inhibit the hepatic metabolism or carbamazepine and levels; may cause toxicity

• Enzyme inducers such as rifampin, phenobarbital, phenytoin, primidone, and methosuximide may serum concentration of carbamazepine

• May risk of hepatotoxicity from isoniazid

• Felbamate carbamazepine levels but levels of active metabolite

• May effectiveness and risk of toxicity from acetaminophen

• May risk of CNS toxicity from lithium

• May duration of action of nondepolarizing neuromuscular blocking agents

Drug-Food
Grapefruit juice serum levels and oral bioavailability by 40% and therefore may effects

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