Interactions

Drug-Drug

• Alcohol, antidepressants, antihistamines, and opioid analgesics —concurrent use results in additive CNS depression

• Cimetidine, oral contraceptives , disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol, or valproic acid may enhance effects

• May efficacy of levodopa

• Rifampin or barbiturates may effectiveness of chlordiazepoxide

• Sedative effects may be by theophylline

Drug-Natural Products
Concomitant use of kava, valerian, chamomile, or hops can CNS depression

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