Interactions

Drug-Drug

• Alcohol , antidepressants , antihistamines , and opioid analgesics —concurrent use results in additive CNS depression

• Cimetidine , oral contraceptives , disulfiram , fluoxetine , isoniazid , ketoconazole , metoprolol , propoxyphene , propranolol , or valproic acid may enhance effects

• May ↓ efficacy of levodopa

• Rifampin or barbiturates may ↓ effectiveness of chlordiazepoxide

• Sedative effects may be ↓ by theophylline

Drug-Natural Products
Concomitant use of kava-kava , valerian , chamomile , or hops can ↑ CNS depression

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