Interactions

Drug-Drug

• Antacids may ↓ absorption (separate administration of these agents by at least 4 hr)

• Blood levels may be ↑ by cimetidine, fluconazole, ketoconazole, clarithromycin, erythromycin, fluoxetine, nefazodone, paroxetine, protease inhibitors, quinidine, ritonavir, and verapamil (concurrent use with cimetidine , should be avoided)

• May ↓ absorption of ampicillin (separate administration of these agents by at least 2 hr)

• May ↑ blood levels of cyclosporine, fluoxetine, lidocaine, mirtazapine, nefazodone, paroxetine, risperidone, ritonavir, thioridazine, tricyclic antidepressants, and venlafaxine

• Blood levels may be ↓ by carbamazepine, nevirapine, phenobarbital, phenytoin, and rifampin

• May ↑ the risk of hepatotoxicity when administered with other hepatotoxic agents

• Urinary acidifiers may ↑ renal excretion and ↓ effectiveness

• Concurrent use with mefloquine may ↑ risk of seizures

Drug-Food
Foods that acidify urine (see Food Sources for Specific Nutrients) may ↑ excretion and ↓ effectiveness

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