Interactions

Drug-Drug

• Antacids may decrease absorption

• Blood levels may be increased by cimetidine, fluconazole, ketoconazole, clarithromycin, erythromycin, fluoxetine, nefazodone, paroxetine, protease inhibitors, quinidine, ritonavir, and verapamil

• May decrease absorption of ampicillin (separate administration of these agents by at least 2 hr)

• May increase blood levels of cyclosporine, fluoxetine, lidocaine, mirtazapine, nefazodone, paroxetine, risperidone, ritonavir, thioridazine, tricyclic antidepressants, and venlafaxine

• Blood levels may be decreased by carbamazepine, nevirapine, phenobarbital, phenytoin, and rifampin

• May increase the risk of hepatotoxicity when administered with other hepatotoxic agents

• Urinary acidifiers may increase renal excretion and decrease effectiveness

Drug-Food
Foods that acidify urine (see Food Sources for Specific Nutrients) may increase excretion and decrease effectiveness

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