Route/Dosage

• Doses below expressed as chloroquine base: 1 mg of chloroquine base = 1.67 mg chloroquine phosphate or 1.25 mg chloroquine hydrochloride

• PO (Adults): 300 mg once weekly, starting 2 wk prior to entering endemic areas and for 8 wk afterward. If suppressive therapy is not initiated prior to entering endemic area, initial dose should be 300 mg followed by another 300 mg dose 6 hr later, followed by the usual dosage regimen.

• PO (Children): 5 mg/kg once weekly, starting 2 wk prior to entering endemic areas and for 8 wk afterward (not to exceed 300 mg/day).If suppressive therapy is not initiated prior to entering endemic area, initial dose should be 5 mg/kg followed by another 5 mg/kg dose 6 hr later, followed by the usual dosage regimen.

• PO (Adults): 600 mg initially, then 300 mg at 6–8 hr, 24 hr, and 48 hr after initial dose.

• PO (Children): 10 mg/kg initially (not to exceed 600 mg), then 5 mg/kg at 6 hr, 24 hr, and 48 hr after initial dose (not to exceed 300 mg/day).

• PO (Adults): 600 mg daily for 2 days, then 300 mg daily for at least 2–3 wk (in combination with other antiprotozoals).

• PO (Children): 10 mg/kg (not to exceed 300 mg/day for 2–3 wk.

• PO (Adults): 150 mg once daily; reduce dosage following maximal response.

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