Pharmacokinetics

Absorption: Variable absorption from tablets/suppositories; better with oral liquid formulations. Well absorbed following IM administration

Distribution: Widely distributed; high CNS concentrations. Crosses the placenta; enters breast milk

Protein Binding: >= 90%

Metabolism and Excretion: Highly metabolized by the liver and GI mucosa. Some metabolites are active

Half-life: 30 hr

TIME/ACTION PROFILE (antipsychotic activity, antiemetic activity, sedation)

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