Interactions

Drug-Drug

• Concurrent use with pimozide the risk of potentially serious cardiovascular reactions

• May alter serum phenytoin levels

• pressor effect of norepinephrine and eliminates bradycardia

• Antagonizes peripheral vasoconstriction from epinephrine and may reverse some of its actions

• May elimination and effects of valproic acid

• May the pharmacologic effects of amphetamine and related compounds

• May the effectiveness of bromocriptine

• May blood levels and effects of tricyclic antidepressants

• Antacids or adsorbent antidiarrheals may adsorption; administer 1 hr before or 2 hr after chlorpromazine

• Activated charcoal absorption

• risk of anticholinergic effects with antihistamines, tricyclic antidepressants, quinidine, or disopyramide

• Premedication with chlorpromazine the risk of neuromuscular excitation and hypotension when followed by barbiturate anesthesia

• Barbiturates may metabolism and effectiveness

• Chlorpromazine may barbiturate blood levels

• Additive hypotension with antihypertensives

• Additive CNS depression with alcohol, antidepressants, antihistamines, MAO inhibitors, opioid analgesics, sedative/hypnotics, or general anesthetics

• Concurrent use with lithium may produce disorientation, unconsciousness, or extrapyramidal symptoms

• Concurrent use with meperidine may produce excessive sedation and hypotension

• May the risk of seizures with subarachnoid metrizamide

• Concurrent use with propranolol blood levels of both drugs

• Concomitant use of kava, valerian, chamomile, or hops can CNS depression

• anticholinergic effects with angel's trumpet, jimson weed, and scopolia

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