Route/Dosage

• PO (Adults):
Psychoses—10–25 mg 2–4 times daily; may increase every 3–4 days (usual dose is 200 mg/day; up to 1 g/day).
Nausea and vomiting—10–25 mg q 4 hr as needed.
Preoperative sedation—25–50 mg 2–3 hr before surgery.
Hiccups/porphyria—25–50 mg 3–4 times daily.

• PO (Children):
Psychoses/nausea and vomiting—0.55 mg/kg (15 mg/m²) q 4–6 hr as needed.
Preoperative sedation—0.55 mg/kg (15 mg/m²) 2–3 hr before surgery.

• IM (Adults):
Severe psychoses—25–50 mg initially, may be repeated in 1 hr; increase to maximum of 400 mg q 3–12 hr if needed (up to 1 g/day).
Nausea/vomiting —25 mg initially, may repeat with 25–50 mg q 3–4 hr as needed.
Nausea/vomiting during surgery—12.5 mg, may be repeated in 30 min as needed.
Preoperative sedation—12.5–25 mg 1–2 hr prior to surgery.
Hiccups/tetanus—25–50 mg 3–4 times daily.
Porphyria—25 mg q 6–8 hr until patient can take PO.

• IM (Children >6 mo):
Psychoses/nausea and vomiting—0.55 mg/kg (15 mg/m²) q 6–8 hr (not to exceed 40 mg/day in children 6 mo–5 yr, or 75 mg/day in children 5–12 yr).
Nausea/vomiting during surgery—0.275 mg/kg, may repeat in 30 min as needed.
Preoperative sedation—0.55 mg/kg 1–2 hr prior to surgery.
Tetanus—0.55 mg/kg q 6–8 hr.

• IV (Adults):
Nausea/vomiting during surgery—up to 25 mg.
Hiccups/tetanus—25–50 mg.
Porphyria—25 mg q 8 hr.

• IV (Children):
Nausea/vomiting during surgery—0.275 mg/kg.
Tetanus—0.55 mg/kg.

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