Route/Dosage
• PO (Adults): 250 mg once daily, initially; may increase dose by 50–125 mg/day at 3–5 day intervals. Maximum daily dose is 750 mg.
Older, debilitated or malnourished patients—initiate therapy with 100–125 mg once daily; may increase dose by 50–125 mg/day at 3–5 day intervals. Maximum daily dose is 750 mg.
Antidiuretic dose—100–250 mg/day.
Hepatic Impairment• PO (Adults): initiate therapy with 100–125 mg/day.
Renal Impairment• PO (Adults CCr >= 50 ml/min): initiate therapy with 100–125 mg once daily.
Renal Impairment• PO (Adults CCr < 50 ml/min): Avoid use.
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