General
Pronunciation
konn-DROY-tinn
Trade Name(s)
chondroitin polysulfate
CPS
CDS
Ther. class.nonopioid analgesicsAction
May serve as a building block of articular cartilage. May protect cartilage against degradation. May have antiatherogenic properties
Therapeutic Effect(s):
Improvement in osteoarthritis symptoms
Pharmacokinetics
Absorption: Unknown
Distribution: Unknown
Metabolism and Excretion: Unknown
Half-life: Unknown
TIME/ACTION PROFILE
| ROUTE | ONSET | PEAK | DURATION |
| PO | unknown | unknown | unknown |
Contraindication/Precautions
Contraindicated in:
Pregnancy and lactation
Use Cautiously in:
Asthma (may exacerbate symptoms)
Clotting disorders (may increase risk of bleeding)
Prostate cancer (may increase risk of metastasis or recurrence)
Adverse Reactions/Side Effects
GI: heartburn, nausea, diarrhea.
Hemat: bleeding (antiplatelet effect).
Misc: allergic reactions, edema, hair loss.
*CAPITALS indicates life-threatening.
*italic indicates most frequent.
Interactions
Natural Products-Drug
Use of chondroitin with anticoagulant and antiplatelet drugs, thrombolytics, NSAIDs, some cephalosporins, and valproates may increase risk of bleeding
Natural Products-Natural Products
Herbs with anticoagulant or antiplatelet properties may increase bleeding risk when combined with chondroitin, including: anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, ginger, ginkgo, Panax ginseng, licorice, and others
Route/Dosage
PO (Adults):
Osteoarthritis200400 mg 23 times daily or 10001200 mg once daily.
Prevention of recurrent myocardial infarction-10 grams daily in 3 divided doses for 3 months.
IM (Adults):
Osteoarthritis50 mg twice weekly for 8 weeks every 4 months.
Availability
TabletsOTC
CapsulesOTC
Injection (not available in US)
Ophthalmic Drops Rx in combination with sodium hyaluronate (Viscoat)
Assessment
Evaluate drug profile before starting therapy with this herbal supplement. If the patient is taking anticoagulants or antiplatelet drugs, avoid use of this herb
Monitor pain (type, location and intensity) and range of motion on an ongoing basis as an indicator of drug efficacy
Evaluate gastric discomfort and instruct patient to seek out the advice of a health care provider if persistent gastric discomfort occurs
Assess for signs of bleeding and discontinue herbal supplement promptly and seek out healthcare professional for follow up
Potential Nursing Diagnoses
Acute pain
Impaired physical mobility
Implementation
Take with food
Patient/Family Teaching
Advise patients that this herbal supplement is usually taken with glucosamine
Caution patients who take aspirin or NSAIDs or other nonprescription medications not to take this herbal supplement without conferring with their health care provider
Warn women taking this herbal supplement to stop it if they suspect they are pregnant, and not to use it if they are breast feeding
Instruct patients that this medication works by building up cartilage and that this requires that the medication be taken consistently over a period of time. It is not recommended as a supplemental pain medication
Evaluation/Desired Outcomes
Improvement in pain and range of motion
Reduced need for supplemental or breakthrough pain medication
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