Pharmacokinetics

Absorption: Rapidly absorbed (50%) after oral administration

Distribution: Widely distributed; tissue levels may exceed those in serum

Protein Binding: 65–70%

Metabolism and Excretion: 10–15% converted by the liver to 14-hydroxyclarithromycin, which has anti-infective activity; 20–30% excreted unchanged in urine. Metabolized by and also inhibits the CYP3A enzyme system

Half-life: Dose-dependent and prolonged with renal dysfunction250-mg dose—3–4 hr; 500-mg dose—5–7 hr

TIME/ACTION PROFILE (serum levels)

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