Interactions

Drug-Drug

• Clarithromycin is an inhibitor of the CYP3A enzyme system. Concurrent use with other agents metabolized by this system can levels and risk of toxicity

• May prolong the QT interval and risk of arrhythmias with pimozide ; concurrent use is contraindicated

• Similar effects may occur with antiarrhythmics; ECG should be monitored for QTc prolongation and serum levels monitored

• May serum levels and the risk of toxicity from carbamazepine, some benzodiazepines (midazolam, triazolam, alprazolam), cyclosporine, buspirone, disopyramide, ergot alkaloids, felodipine, omeprazole, tacrolimus, digoxin, or theophylline

• Ritonavir increases blood levels ( clarithromycin dose in patients with CC <60 ml/min)

• levels of HMG-CoA reductase inhibitors and may risk of rhabdomyolysis

• May effect of warfarin and sildenafil (dose reduction may be warranted)

• May or effects of zidovudine

• Blood levels are by delavirdine and fluconazole

• Blood levels may be by rifampin and rifabutin. risk of colchicine toxicty when administered with colchicine, especially in the elderly

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