Interactions

Drug-Drug

• Additive CNS depression with other CNS depressants, including alcohol, opioid analgesics, and sedative/hypnotics

• May antagonize effects of cholinergic agonists (e.g. tacrine, donepezil)

Drug-Natural Products
Concomitant use of kava, valerian, skullcap, chamomile, or hops can increase CNS depression

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