Implementation

• PO: Administer with a full glass of water. May be given with or without meals. Shake liquid preparations well. Do not refrigerate. Stable for 14 days at room temperature

• IM: Do not administer >600 mg in a single IM injection

• Intermittent Infusion:
Diluent: Vials must be diluted before use. Dilute a dose of 300 mg or 600 mg in 50 ml and a dose of 900 mg or 1200 mg in 100 ml. Compatible diluents include D5W, 0.9% NaCl, D5/0.9% NaCl, D5/0.45% NaCl, or LR. Admixed solution stable for 16 days at room temperature. Premixed infusion is already diluted and ready to use.
Concentration: Not to exceed 18 mg/ml

• Rate:
Not exceed 30 mg/min. Hypotension and cardiopulmonary arrest have been reported following rapid IV administration

• Y-Site Compatibility:

» acyclovir

» amifostine

» amikacin

» aminophylline

» amiodarone

» amphotericin B cholesteryl sulfate

» amsacrine

» anakinra

» anidulafungin

» atropine

» aztreonam

» bumetanide

» bivalirudin

» calcium chloride

» calcium gluconate

» cefazolin

» cefotaxime

» cefoxitin

» ceftazidime

» ceftizoxime

» cefuroxime

» chloramphenicol

» cimetidine

» cisatracurium

» cyclosporine

» daptomycin

» dexamethasone sodium phosphate

» dexmedetomidine

» digoxin

» diltiazem

» diphenhydramine

» docetaxel

» dopamine

» doxorubicin liposome

» doxycycline

» enalaprilat

» epinephrine

» esmolol

» etoposide phosphate

» famotidine

» fenoldopam

» fentanyl

» fludarabine

» foscarnet

» furosemide

» gentamicin

» granisetron

» heparin

» hydrocortisone sodium succinate

» hydromorphone

» imipenem/cilastatin

» insulin

» isoproterenol

» ketorolac

» labetalol

» levofloxacin

» lidocaine

» linezolid

» lorazepam

» magnesium sulfate

» melphalan

» meperidine

» methylprednisolone sodium succinate

» metoclopramide

» metoprolol

» metronidazole

» midazolam

» milrinone

» morphine

» multivitamins

» nafcillin

» nicardipine

» nitroglycerin

» nitroprusside

» norepinephrine

» ondansetron

» palonosetron

» pantoprazole

» pemetrexed

» penicillin G potassium

» perphenazine

» phenylephrine

» phytonadione

» piperacillin/tazobactam

» potassium chloride

» procainamide

» propofol

» propranolol

» protamine

» ranitidine

» remifentanil

» sargramostim

» sodium bicarbonate

» tacrolimus

» teniposide

» theophylline

» thiotepa

» ticarcillin/clavulanate

» tirofiban

» tobramycin

» vancomycin

» vasopressin

» verapamil

» vinorelbine

» vitamin B complex with C

» voriconazole

» zidovudine

• Y-Site Incompatibility:

» allopurinol

» azithromycin

» caspofungin

» ceftriaxone

» diazepam

» filgrastim

» fluconazole

» ganciclovir

» haloperidol

» hydroxyzine

» idarubicin

» lansoprazole

» phenytoin

» prochlorperazine

» promethazine

» quinupristin/dalfopristin

» trimethoprim/sulfamethoxazole

• Vag: Applicators are supplied for vaginal administration. When treating bacterial vaginosis, concurrent treatment of male partner is not usually necessary

• Topical: Contact with eyes, mucous membranes, and open cuts should be avoided during topical application. If accidental contact occurs, rinse with copious amounts of cool water

» Wash affected areas with warm water and soap, rinse, and pat dry prior to application. Apply to entire affected area

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