Pharmacokinetics

Absorption: Well absorbed from the GI tract

Distribution: Widely distributed, enters breast milk

Protein Binding: >=90%

Metabolism and Excretion: Extensively metabolized by the liver. Some conversion to a pharmacologically active metabolite (desmethylclomipramine). Undergoes enterohepatic recirculation and secretion into gastric juices

Half-life: 21–31 hr

TIME/ACTION PROFILE

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