Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Angle-closure glaucoma

• Recent myocardial infarction

• History of QTc prolongation

• Cardiac arrythmias

• Heart failure

• Concurrent MAO inhibitor or clonidine use (avoid if possible)

• OB: Potential for fetal harm or neonatal withdrawal syndrome

• Lactation: Discontinue drug or bottle feed

• History of seizures (threshold may be lowered)

• Patients with pre-existing cardiovascular disease

• Older men with prostatic hyperplasia (may be more susceptible to urinary retention)

• Hyperthyroidism (increased risk of arrhythmias)

• May risk of suicide attempt/ideation especially during dose early treatment or dose adjustment; risk may be greater in children or adolescents

• Pedi: Safety not established in children <10 yr

• Geri: risk of arrhythmias

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