Interactions

Drug-Drug

• Alcohol , antidepressants , antihistamines , other benzodiazepines , and opioid analgesics —concurrent use results in ↑ CNS depression

• Cimetidine , hormonal contraceptives , disulfiram , fluoxetine , isoniazid , ketoconazole , metoprolol , propoxyphene , propranolol , or valproic acid may ↓ metabolism of clonazepam, ↑ its actions

• May ↓ efficacy of levodopa

• Rifampin or barbiturates may ↑ metabolism and ↓ effectiveness of clonazepam

• Sedative effects may be ↓ by theophylline

• May ↑ serum phenytoin levels

• Phenytoin may ↓ serum clonazepam levels

Drug-Natural Products
Concomitant use of kava-kava , valerian , or chamomile can ↑ CNS depression

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