Davis's Drug Guide
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clopidogrel

Pharmacokinetics

Absorption: Well absorbed following oral administration; rapidly metabolized to an active antiplatelet compound. Parent drug has no antiplatelet activity.

Distribution: Unknown.

Protein Binding: Clopidogrel—98%; active metabolite—94%.

Metabolism and Excretion: Rapidly and extensively converted by the liver (CYP2C19) to its active metabolite, which is then eliminated 50% in urine and 45% in feces;2% of Whites, 4% of Blacks, and 14% of Asians have CYP2C19 genotype that results in reduced metabolism of clopidogrel (poor metabolizers) into its active metabolite (may result in ↓ antiplatelet effects).

Half-life: 8 hr (active metabolite).

TIME/ACTION PROFILE (effects on platelet function)

ROUTEONSETPEAKDURATION
POwithin 24 hr3–7 days5 days†

†Following discontinuation

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