Pharmacokinetics

Absorption: Well absorbed following oral administration; rapidly metabolized to an active antiplatelet compound. Parent drug has no antiplatelet activity.

Distribution: Unknown

Protein Binding: Clopidogrel—98%;active metabolite— 94%

Metabolism and Excretion: Rapidly and extensively converted by the liver to its active metabolite, which is then eliminated 50% in urine and 45% in feces

Half-life: 8 hr (active metabolite)

TIME/ACTION PROFILE (effects on platelet function)

ROUTE	ONSET	PEAK	DURATION
PO	within 24 hr	3–7 days	5 days†

†Following discontinuation

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