Davis's Drug Guide
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clopidogrel

Interactions

Drug-Drug

• Concurrent abciximab , eptifibatide , tirofiban , aspirin , NSAIDs , heparin , LMWHs , thrombolytic agents , ticlopidine , or warfarin may ↑ risk of bleeding.

• May ↓ metabolism and ↑ effects of phenytoin , tolbutamide , tamoxifen , torsemide , fluvastatin , and many NSAIDs .

• Concurrent use of strong or moderate CYP2C19 inhibitors (e.g. omeprazole , esomeprazole , cimetidine , fluconazole , ketoconazole , voriconazole , etravirine , felbamate , fluoxetine , or fluvoxamine ) may ↓ antiplatelet effects (concurrent use should be avoided).

Drug-Natural Products
↑ bleeding risk with anise , arnica , chamomile , clove , fenugreek , feverfew , garlic , ginger , ginkgo , Panax ginseng , and others.

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