Pharmacokinetics

Absorption: Well absorbed following oral administration

Distribution: Crosses the blood-brain barrier and placenta

Protein Binding: >90%

Metabolism and Excretion: 50% metabolized by the liver; 50% excreted unchanged by the kidneys

Half-life: 20–36 hr (prolonged in renal impairment)

TIME/ACTION PROFILE

ROUTE	ONSET	PEAK	DURATION
PO†	1 hr	8–12 hr	8 hr
IV‡	immediate	5 min	3–12 hr

†Blood sugar
‡Blood pressure

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