Pharmacokinetics

Absorption: Undergoes first-pass metabolism by liver which results in 50% bioavailability Oral diclofenac sodium is a delayed-release dosage form. Diclofenac potassium is an immediate-release dosage form. 10% of topically applied diclofenac is systemically absorbed

Distribution: Crosses the placenta

Protein Binding: >99%

Metabolism and Excretion: Metabolized by the liver to several metabolites; 65% excreted in urine, 35% in bile

Half-life: 2 hr

TIME/ACTION PROFILE

ROUTE	ONSET	PEAK	DURATION
PO (inflammation)	few days–1 wk	2 wk or more	unknown
PO (pain)	30 min	unknown	up to 8 hr
Topical	unknown	30 days*	unknown

*Complete healing of lesions following cessation of therapy

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