Contraindication/Precautions

Contraindicated in:

• Hypersensitivity to diclofenac or other components of formulation

• Cross-sensitivity may occur with other NSAIDs including aspirin

• Active GI bleeding/ulcer disease

• Patients undergoing coronary artery bypass graft surgery

• Severe renal/hepatic disease

• Cardiovascular disease or risk factors for cardiovascular disease (may risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use)

• History of porphyria

• History of peptic ulcer disease and/or GI bleeding

• Geri: Geriatric patients (dosage reduction recommended; more susceptible to adverse reactions, including GI bleeding)

• Bleeding tendency or concurrent anticoagulant therapy

• OB: /Lactation: Pregnancy and lactation (not recommended for use during second half of pregnancy)

• Pedi: Pregnancy, lactation, and children (safety not established)

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