Route/Dosage

• Different formulations of oral diclofenac (diclofenac sodium enteric-coated tablets, diclofenac sodium extended-release tablets, and diclofenac potassium immediate-release tablets are not bioequivalent and should not be substituted on a mg-to-mg basis.

• PO (Adults):
Analgesic/antidysmenorrheal—100 mg initially, then 50 mg 3 times daily as needed;
Rheumatoid arthritis—50 mg 3–4 times daily, after initial response reduce to lowest dose that controls symptoms;
Osteoarthritis—50 mg 2–3 times daily, after initial response reduce to lowest dose that controls symptoms.

• PO (Adults):
Rheumatoid arthritis (delayed-release [enteric-coated] tablets)—50 mg 3–4 times daily
or 75 mg twice daily; after initial resopnse reduce to lowest dose that controls symptoms (usual maintenance dose 25 mg 3 times daily).
Rheumatoid arthritis (extended-release tablets)—100 mg once daily, if unsatisfactory response, dose may be to 100 mg twice daily.
Osteoarthritis (delayed-release [enteric-coated] tablets)—50 mg 2–3 times daily
or 75 mg twice daily; after initial response, to lowest dose that controls symptoms.
Osteoarthritis (extended-release tablets)—100 mg once daily.
Ankylosing spondylitis (delayed-release [enteric-coated] tablets)- 25 mg 4 times daily, with an additional 25 mg given at bedtime, if necessary.

• Topical (Adults): Apply to lesions twice daily for 60–90 days.

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