Implementation

• Do not confuse Benadryl (diphenhydramine) with Benylin (dextromethorphan), desipramine (Norpramin) or with dimenhydrinate (Dramamine)

» When used for insomnia, administer 20 min before bedtime and schedule activities to minimize interruption of sleep

» When used for prophylaxis of motion sickness, administer at least 30 min and preferably 1–2 hr before exposure to conditions that may precipitate motion sickness

• PO: Administer with meals or milk to minimize GI irritation. Capsule may be emptied and contents taken with water or food

• IM: Administer 50 mg/ml into well-developed muscle. Avoid subcut injections

• Direct IV:
Diluent: May be further diluted in 0.9% NaCl, 0.45% NaCl, D5W, D10W, dextrose/saline combinations, Ringer's solution, LR, and dextrose/Ringer's combinations.
Concentration: 25 mg/ml

• Rate:
Infuse over 10–15 min at a rate not to exceed25 mg/min

• Syringe Compatibility:

» atropine

» butorphanol

» chlorpromazine

» cimetidine

» dimenhydrinate

» droperidol

» fentanyl

» fluphenazine

» glycopyrrolate

» hydromorphone

» hydroxyzine

» meperidine

» metoclopramide

» midazolam

» morphine

» nalbuphine

» pentazocine

» perphenazine

» prochlorperazine

» promethazine

» ranitidine

» scopolamine

» sufentanil

• Syringe Incompatibility:

» haloperidol

» pentobarbital

» thiopental

• Y-Site Compatibility:

» abciximab

» acyclovir

» aldesleukin

» amifostine

» amsacrine

» argatroban

» azithromycin

» aztreonam

» bivalirudin

» ciprofloxacin

» cisatracurium

» cisplatin

» cladribine

» cyclophosphamide

» cytarabine

» dexmedetomidine

» docetaxel

» doxorubicin

» doxorubicin liposome

» etoposide phosphate

» famotidine

» fenoldopam

» fentanyl

» filgrastim

» fluconazole

» fludarabine

» gemcitabine

» granisetron

» heparin

» hydrocortisone

» hydromorphone

» idarubicin

» linezolid

» melphalan

» meperidine

» meropenem

» methadone

» methotrexate

» morphine

» ondansetron

» oxaliplatin

» paclitaxel

» pemetrexed

» piperacillin/tazobactam

» potassium chloride

» propofol

» remifentanil

» sargramostim

» sufentanil

» tacrolimus

» teniposide

» thiotepa

» vinorelbine

» vitamin B complex with C

• Y-Site Incompatibility:

» allopurinol

» amphotericin B cholesteryl sulfate

» cefepime

» foscarnet

» lansoprazole

diphenhydrAMINE is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.