Interactions

Drug-Drug

• risk of CNS depression with other antihistamines, alcohol, opioid analgesics, and sedative/hypnotics

• anticholinergic effects with tricyclic antidepressants, quinidine, or disopyramide

• MAO inhibitors intensify and prolong the anticholinergic effects of antihistamines

Drug-Natural Products
Concomitant use of kava, valerian, or chamomile, can CNS depression

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