Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Congenital or acquired prolonged QT syndromes

• Baseline QT interval or QTc of >440 msec (500 msec in patients with ventricular conduction abnormalities)

• Creatinine clearance (CCr) <20 ml/min

• Concurrent use of verapamil or agents which inhibit the renal cation transport system including cimetidine, ketoconazole, trimethoprim, megestrol or prochlorperazine

• Concurrent use of hydrochlorothiazide

• OB: Lactation (use should be avoided)

• Underlying electrolyte abnormalities (increased risk of serious arrhythmias; correct prior to administration)

• CCr 20–60 ml/min (dosage reduction recommended)

• Severe hepatic impairment

• OB: Pregnancy (use only when benefit to patient outweighs potential risk to fetus)

• Pedi: Children <18 yr (safety not established)

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