Interactions

Drug-Drug

• Additive CNS depression with alcohol, antihistamines, barbiturates, benzodiazepines, atropine, scopolamine, lithium, buspirone, muscle relaxants, opioid analgesics, tricyclic antidepressants, and sedative/hypnotics

• Increased risk of tachycardia with amphetamine, atropine, scopolamine, cocaine, sympathomimetics, antihistamines, and tricyclic antidepressants

• May increase blood levels of theophylline

• Increased risk of tachycardia with caffeine -containing herbs (cola nut, guarana, mate, tea, coffee)

• Concomitant use of kava, valerian, skullcap, chamomile, or hops can increase CNS depression

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