Pharmacokinetics

Absorption: Well absorbed following IM administration

Distribution: Appears to cross the blood-brain barrier and placenta

Metabolism and Excretion: Mainly metabolized by the liver. Only 10% excreted unchanged by the kidneys

Half-life: 2.2 hr

TIME/ACTION PROFILE (sedation)

ROUTE	ONSET	PEAK	DURATION*
IM, IV	3–10 min	30 min	2–4 hr

*Listed as duration of tranquilization; alterations in consciousness may last up to 12 hr

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