Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Patients with a high risk of bleeding, including those with

» active internal bleeding

» recent (within 3 months) stroke

» recent (within 2 months) intracranial or intraspinal injury or severe head trauma

» any trauma associated with an increased risk of life-threatening bleeding

» presence of an epidural catheter

» intracranial neoplasm/mass lesion/cerebral herniation

• Patients not expected to survive due to pre-existing medical condition(s)

• HIV-positive patients with CD-4 cell counts <=50/mm³

• Chronic dialysis patients

• Patients who have undergone bone marrow, lung, liver, pancreas or small bowel transplantation

• OB: Lactation

• Concurrent therapeutic heparin therapy (>=15 units/kg/hr), recent (within 3 days) thrombolytic therapy, recent (within 7 days) oral anticoagulants or glycoprotein IIb/IIIa inhibitors, recent (within 7 days) aspirin therapy > 650 mg/day or other platelet inhibitors

• Platelet count <30,000 x 10⁶/L

• Prothrombin time—INR >3.0

• Recent (within 6 wk) GI bleeding

• Recent (within 3 mos) ischemic stroke

• Intracranial arteriovenous malformation or aneurysm

• Known bleeding diathesis

• Chronic severe hepatic disease

• Any other serious bleeding risk

• Surgical procedures (discontinue 2 hr before; resume 12 hr after if hemostasis is achieved)

• OB: Pregnancy (use only if clearly needed)

• Pedi: Children (safety not established)

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